Preparatory Signal Detection for the EU-27 Member States Under EU Burden Sharing - Advanced Monitoring Including Uncertainty (1990-2006)

This study follows up IIASA Interim Report IR-04-024 (Jonas et al., 2004), which addresses the preparatory detection of uncertain greenhouse gas (GHG) emission changes (also termed emission signals) under the Kyoto Protocol. The question probed was how well do we need to know net emissions if we want to detect a specified emission signal after a given time? The authors used the Protocol's Annex B countries as net emitters and referred to all Kyoto GHGs (CO2, CH4, N2O, HFCs, PFCs, and SF6) excluding CO2 emissions/removals due to land-use change and forestry (LUCF). They motivated the application of preparatory signal detection in the context of the Kyoto Protocol as a necessary measure that should have been taken prior to/in negotiating the Protocol. The authors argued that uncertainties are already monitored and are increasingly made available but that monitored emissions and uncertainties are still dealt with in isolation. A connection between emission and uncertainty estimates for the purpose of an advanced country evaluation has not yet been established. The authors developed four preparatory signal analysis techniques and applied these to the Annex B countries under the Kyoto Protocol. The frame of reference for preparatory signal detection is that Annex B countries comply with their agreed emission targets in 2008-2012. The emissions path between base year and commitment year/period is generally assumed to be a straight line, and emissions prior to the base year are not taken into consideration. An in-depth quantitative comparison of the four, plus two additional, preparatory signal analysis techniques has been prepared by Jonas et al. (2010). This study applies the strictest of these techniques, the combined undershooting and verification time (Und&VT) concept to advance the monitoring of the GHG emissions reported by the 27 Member States of the European Union (EU). In contrast to the study by Jonas et al. (2004), the Member States. agreed emission targets under EU burden sharing in compliance with the Kyoto Protocol are taken into account, however, still assuming that only domestic measures will be used (i.e., excluding Kyoto mechanisms). The Und&VT concept is applied in a standard mode, i.e., with reference to the Member States' agreed emission targets in 2008-2012, and in a new mode, i.e., with reference to linear path emission targets between base year and commitment year. Here, the intermediate year of reference is 2006. To advance the reporting of the EU, uncertainty and its consequences are taken into consideration, i.e., (i) the risk that a Member State's true emissions in the commitment year/period are above its true emission limitation or reduction commitment (true emission target); and (ii) the detectability of the Member State's agreed emission target. This risk can be grasped and quantified although true emissions are unknown by definition. Undershooting the agreed target or the compatible but detectable target can decrease this risk. The Member States' undershooting options and challenges as of 2006 are contrasted with their actual emission situation in that year, which is captured by the distance-to-target-path indicator (DTPI; formerly: distance-to-target indicator) initially introduced by the European Environment Agency. This indicator measures by how much the emissions of a Member State deviate from its linear emissions path between base year and target year. In 2006 thirteen EU-27 Member States exhibit a negative DTPI (not counting Belgium with a DTPI ~= 0) and thus appear as potential sellers: Bulgaria, the Czech Republic, Estonia, France, Germany, Hungary, Latvia, Lithuania, Poland, Romania, Slovakia, Sweden and the United Kingdom. However, expecting that all of the EU Member States will eventually exhibit relative uncertainties in the range of 5.10% and above rather than below (excluding LUCF and Kyoto mechanisms), the Member States require considerable undershooting of their EU-compatible but detectable targets if one wants to keep the said risk low that the Member States' true emissions in the commitment year/period fall above their true emission targets. As of 2006, these conditions can only be met by ten (nine new and one old) Member States (ranked in terms of credibility): Estonia, Latvia, Lithuania, Bulgaria, Romania, Slovakia, Hungary, Poland, the Czech Republic and the United Kingdom; while three old Member States, Germany, Sweden and France, can only act as potential sellers with a higher risk. The other EU-27 Member States do not meet their linear path (base year--commitment year) undershooting targets as of 2005 (i.e., they overshoot their intermediate targets), or do not have Kyoto targets at all (Cyprus and Malta). The relative uncertainty, with which countries report their emissions, matters. For instance, with relative uncertainty increasing from 5 to 10%, the 2008/12 emission reduction of the EU-15 as a whole (which has jointly approved, as a Party, an 8% emission reduction under the Kyoto Protocol) switches from detectable to non-detectable, indicating that the negotiations for the Kyoto Protocol were imprudent because they did not take uncertainty and its consequences into account. It is anticipated that the evaluation of emission signals in terms of risk and detectability will become standard practice and that these two qualifiers will be accounted for in pricing GHG emission permits

Exploratory Analysis of Highly Heterogeneous Document Collections

We present an effective multifaceted system for exploratory analysis of highly heterogeneous document collections. Our system is based on intelligently tagging individual documents in a purely automated fashion and exploiting these tags in a powerful faceted browsing framework. Tagging strategies employed include both unsupervised and supervised approaches based on machine learning and natural language processing. As one of our key tagging strategies, we introduce the KERA algorithm (Keyword Extraction for Reports and Articles). KERA extracts topic-representative terms from individual documents in a purely unsupervised fashion and is revealed to be significantly more effective than state-of-the-art methods. Finally, we evaluate our system in its ability to help users locate documents pertaining to military critical technologies buried deep in a large heterogeneous sea of information.Comment: 9 pages; KDD 2013: 19th ACM SIGKDD Conference on Knowledge Discovery and Data Minin

Preparatory Signal Detection for the EU-27 Member States Under EU Burden Sharing - Advanced Monitoring Including Uncertainty (1990-2007)

This study follows up IIASA Interim Report IR-04-024 (Jonas et al., 2004), which addresses the preparatory detection of uncertain greenhouse gas (GHG) emission changes (also termed emission signals) under the Kyoto Protocol. The question probed was how well do we need to know net emissions if we want to detect a specified emission signal after a given time? The authors used the Protocol's Annex B countries as net emitters and referred to all Kyoto GHGs (CO2, CH4, N2O, HFCs, PFCs, and SF6) excluding CO2 emissions/removals due to land-use change and forestry (LUCF). They motivated the application of preparatory signal detection in the context of the Kyoto Protocol as a necessary measure that should have been taken prior to/in negotiating the Protocol. The authors argued that uncertainties are already monitored and are increasingly made available but that monitored emissions and uncertainties are still dealt with in isolation. A connection between emission and uncertainty estimates for the purpose of an advanced country evaluation has not yet been established. The authors developed four preparatory signal analysis techniques and applied these to the Annex B countries under the Kyoto Protocol. The frame of reference for preparatory signal detection is that Annex B countries comply with their agreed emission targets in 2008-2012. The emissions path between base year and commitment year/period is generally assumed to be a straight line, and emissions prior to the base year are not taken into consideration. An in-depth quantitative comparison of the four, plus two additional, preparatory signal analysis techniques has been prepared by Jonas et al. (2010). This study applies the strictest of these techniques, the combined undershooting and verification time (Und&VT) concept to advance the monitoring of the GHG emissions reported by the 27 Member States of the European Union (EU). In contrast to the study by Jonas et al. (2004), the Member States' agreed emission targets under EU burden sharing in compliance with the Kyoto Protocol are taken into account, however, still assuming that only domestic measures will be used (i.e., excluding Kyoto mechanisms). The Und&VT concept is applied in a standard mode, i.e., with reference to the Member States' agreed emission targets in 2008-2012, and in a new mode, i.e., with reference to linear path emission targets between base year and commitment year. Here, the intermediate year of reference is 2007. To advance the reporting of the EU, uncertainty and its consequences are taken into consideration, i.e., (i) the risk that a Member State's true emissions in the commitment year/period are above its true emission limitation or reduction commitment (true emission target); and (ii) the detectability of the Member State's agreed emission target. This risk can be grasped and quantified although true emissions are unknown by definition. Undershooting the agreed target or the compatible but detectable target can decrease this risk. The Member States' undershooting options and challenges as of 2007 are contrasted with their actual emission situation in that year, which is captured by the distance-to-target-path indicator (DTPI; formerly: distance-to-target indicator) initially introduced by the European Environment Agency. This indicator measures by how much the emissions of a Member State deviate from its linear emissions path between base year and target year. In 2007, fourteen EU-27 Member States exhibit a negative DTPI and thus appear as potential sellers: Belgium, Bulgaria, Czech Republic, Estonia, France, Germany, Hungary, Latvia, Lithuania, Poland, Romania, Slovakia, Sweden, and the United Kingdom. However, expecting that all of the EU Member States will eventually exhibit relative uncertainties in the range of 5-10% and above rather than below (excluding LUCF and Kyoto mechanisms), the Member States require considerable undershooting of their EU-compatible but detectable targets if one wants to keep the said risk low that the Member States' true emissions in the commitment year/period fall above their true emission targets. As of 2007, these conditions can only be met by ten (nine new and one old) Member States (ranked in terms of credibility): Latvia, Lithuania, Estonia, Romania, Bulgaria, Slovakia, Hungary, Poland, the Czech Republic and the United Kingdom; while four Member States, Germany, Belgium, Sweden and France, can only act as potential sellers with a higher risk. The other EU-27 Member States do not meet their linear path (base year-commitment year) undershooting targets as of 2007 (i.e., they overshoot their intermediate targets), or do not have Kyoto targets at all (Cyprus and Malta). The relative uncertainty, with which countries report their emissions, matters. For instance, with relative uncertainty increasing from 5 to 10%, the 2008/12 emission reduction of the EU-15 as a whole (which has jointly approved, as a Party, an 8% emission reduction under the Kyoto Protocol) switches from detectable to non-detectable, indicating that the negotiations for the Kyoto Protocol were imprudent because they did not take uncertainty and its consequences into account. It is anticipated that the evaluation of emission signals in terms of risk and detectability will become standard practice and that these two qualifiers will be accounted for in pricing GHG emission permits

Deficiency of Phosphoinositide 3-Kinase Enhancer Protects Mice From Diet-Induced Obesity and Insulin Resistance

OBJECTIVE: Phosphoinositide 3-kinase enhancer A (PIKE-A) is a proto-oncogene that promotes tumor growth and transformation by enhancing Akt activity. However, the physiological functions of PIKE-A in peripheral tissues are unknown. Here, we describe the effect of PIKE deletion in mice and explore the role of PIKE-A in obesity development. RESEARCH DESIGN AND METHODS: Whole-body PIKE knockout mice were generated and subjected to high-fat–diet feeding for 20 weeks. The glucose tolerance, tissue-specific insulin sensitivity, adipocyte differentiation, and lipid oxidation status were determined. The molecular mechanism of PIKE in the insulin signaling pathway was also studied. RESULTS: We show that PIKE-A regulates obesity development by modulating AMP-activated protein kinase (AMPK) phosphorylation. PIKE-A is important for insulin to suppress AMPK phosphorylation. The expression of PIKE-A is markedly increased in adipose tissue of obese mice, whereas depletion of PIKE-A inhibits adipocyte differentiation. PIKE knockout mice exhibit a prominent phenotype of lipoatrophy and are resistant to high-fat diet–induced obesity, liver steatosis, and diabetes. PIKE knockout mice also have augmented lipid oxidation, which is accompanied by enhanced AMPK phosphorylation in both muscle and adipose tissue. Moreover, insulin sensitivity is improved in PIKE-A–deficient muscle and fat, thus protecting the animals from diet-induced diabetes. CONCLUSIONS: Our results suggest that PIKE-A is implicated in obesity and associated diabetes development by negatively regulating AMPK activity

使用汉语拼音提高学生的认读能力 (以 DARUL ULUM 回教高中三年级学生为例)

摘要 ：汉语拼音是识字、学习普通话的有效工具。这项研究的目的是提高 学生认读能力。研究对象是 Darul Ulum 高中三年级学生。通过描述性研究 使用汉语拼音教学过程描述，认读汉字和拼音。数据分析的结果说明，使用 汉语拼音可以提高学生的认读能力。通过课堂实施发现，语音的掌握需要通 过课堂上的强化训练。因此可以说，汉语拼音是认读能力的重要因素之一。 关键词： 汉语拼音 汉语拼音教学 认读能力 Abstact : Hanyu Pinyin is a recognize letters, as an effective tool for learning Mandarin language. This study aims to improve students' ability to recognize letters in class XII MA Darul Ulum. Hanyu Pinyin teaching process described by the descriptive study, to recognize and read Chinese characters and Pinyin. The results of data analysis showed that the use of Hanyu Pinyin can improve the students' ability to recognize letters. Through the implementation in the classroom, its proved that mastering Hanzi needs intensive training. Therefore we can say that Hanyu Pinyin is one of the important factor to recognize letters/ Hanzi

Enhanced reliability of vertical strained impact ionization MOSFET incorporating dielectric pocket for ultra-sensitive biosensor applications

Fast switching with an enhanced reliability device structure of Vertical Strained Impact Ionization MOSFET incorporating Dielectric Pocket (VESIMOS-DP) has been successfully design, simulated and analyzed in this paper. Ultra-low power with low subthreshold swing (S) and high breakdown voltage are imperative for ultra-sensitive biosensors. Impact ionization MOSFET (IMOS) is predicted to be capable of S as low as 20 mV/dec, which is much lower than Conventional MOSFET (CMOS). There are significant drop in subthreshold slope (S) while threshold voltage is increase as the body doping concentration increases. S value for DP place at source side is higher (S 24.4 mV/decade) as compared at the drain side (S 18.9 mV/decade) intrinsic region. The vicinity of DP near the drain region reduces charge sharing effects associated with the source and thus improves impact ionization rate. The introduction of a Dielectric Pocket (DP) is believed to be able to minimize the PBT effect while improving the reliability of the device by attaining higher breakdown voltage. Consequently, with the reduced of alloy scattering, the electron mobility has been improved by 22%. In many aspects, it is revealed that the incorporation of DP enhanced the reliability of VESIMOS for future development of nanoelectronic devices

Effects of CO2 on ventilatory and cerebrovascular responses during passive heating in humans

Effects of CO2 on ventilatory and cerebrovascular responses during passive heating in human

Effects of mother-offspring and father-offspring dynamics on emerging adults’ adjustment: The mediating role of emotion regulation

The present study tested a theoretical model of emotion regulation between parent-offspring dynamics and emerging adults’ adjustment. The mediating role of emotion regulation strategies, including cognitive reappraisal and expressive suppression, were investigated for the effects of mother-offspring and father-offspring dynamics on emerging adults’ adjustment. A sample of 352 Chinese emerging adults in Hong Kong (230 female, 121 male) participated in this study. Participants were asked to complete a set of self-reported questionnaires. Findings based on structural equation modeling indicated that greater mother-offspring intimacy and father-offspring intimacy predicted emerging adults’ better cognitive reappraisal and psychological, social, and general health. Greater mother-offspring conflict also predicted more expressive suppression and poorer psychological and social functioning. Distinctive mediation pathways as a function of parents’ gender were identified. These findings enrich the literature for parent-offspring dynamics and emotion regulation as explanatory processes of emerging adults’ adjustment

Long-term impact of pneumococcal polysaccharide vaccination on nasopharyngeal carriage in children previously vaccinated with various pneumococcal conjugate vaccine regimes

Previously, the Fiji Pneumococcal Project (FiPP) evaluated reduced dose immunization schedules that incorporated pneumococcal protein conjugate and/or polysaccharide vaccine (PCV7 and 23vPPV, respectively). Immune hyporesponsiveness was observed in children vaccinated with 23vPPV at 12 months of age compared with children who did not receive 23vPPV.Here we assess the long-term impact of 23vPPV vaccination on nasopharyngeal carriage rates and densities of Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus and Moraxella catarrhalis. Nasopharyngeal swabs (n = 194) were obtained from healthy children who participated in FiPP (now aged 5–7 years). S. pneumoniae were isolated and identified by standard culture-based methods, and serotyped using latex agglutination and the Quellung reaction. Carriage rates and densities of S. pneumoniae, H. influenzae, S. aureus and M. catarrhalis were determined using real-time quantitative PCR.There were no differences in the rate or density of S. pneumoniae, H. influenzae or M. catarrhalis carriage by PCV7 dose or 23vPPV vaccination in the vaccinated participants overall. However, differences were observed between the two main ethnic groups: Fijian children of Indian descent (Indo-Fijian) were less likely to carry S. pneumoniae, H. influenzae and M. catarrhalis, and there was evidence of a higher carriage rate of S. aureus compared with indigenous Fijian (iTaukei) children. Polysaccharide vaccination appeared to have effects that varied between ethnic groups, with 23vPPV vaccination associated with a higher carriage rate of S. aureus in iTaukei children, while there was a lower carriage rate of S. pneumoniae associated with 23vPPV vaccination in Indo-Fijian children.Overall, polysaccharide vaccination had no long-term impact on pneumococcal carriage, but may have impacted on S. aureus carriage and have varying effects in ethnic groups, suggesting current WHO vaccine schedule recommendations against the use of 23vPPV in children under two years of age are appropriate

Thiosquaramides: pH switchable anion transporters

The transport of anions across cellular membranes is an important biological function governed by specialised proteins. In recent years, many small molecules have emerged that mimick the anion transport behaviour of these proteins, but only a few of these synthetic molecules also display the gating/switching behaviour seen in biological systems. A small series of thiosquar-amides was synthesised and their pH-dependent chloride binding and anion transport behaviour was investigated using 1H NMR titrations, single crystal X-ray diffraction and a variety of vesicle-based techniques. Spectrophotometric titrations and DFT calculations revealed that the thiosquaramides are significantly more acidic than their oxosquaramide analogues, with pKa values between 4.0 and 9.0. This led to the observation that at pH 7.2 the anion transport ability of the thiosquaramides is fully switched OFF due to deprotonation of the receptor, but is completely switched ON at lower pH